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This guide provides an orientation to health professionals in developing countries who select to use the collaborative improvement approach to increase the effectiveness of health services such as maternal, newborn, child health, and family planning. The guide is not meant to summarize literature or assemble implementation tools. It is meant to provide practical guidance to potential users of the approach, particularly in the area of maternal, newborn, child health, and family planning, so that they can implement it successfully and measure its impact, with little or no external technical assistance.